Scienceline Publications Journal of Life Science and Biomedicine 2251-9939 8 6 2018 November Acetylation Phenotype Impact on Early Postoperative Period in Viral Liver Cirrhosis 90 93 https://jlsb.science-line.com/attachments/article/64/J.%20Life%20Sci.%20Biomed.%208(6)%2090-93,%202018.pdf EN Ravshan Aliyevich IBADOV Intensive Care Unit, Republican Specialized Scientific–Practical Medical Center of Surgery named after Academician V.Vakhidov, Tashkent, Uzbekistan Oybek Avazkhonovich OMONOV Department of Portal Hypertension and Pancreatoduodenal Zone Surgery, Republican Specialized Scientific–Practical Medical Center of Surgery named after Sardor Khamdamovich IBRAGIMOV Intensive Care Unit, Republican Specialized Scientific–Practical Medical Center of Surgery named after Academician V.Vakhidov, Tashkent, Uzbekistan Objective. The aim of our study was to identify some pathogenetic mechanisms and unify prediction factors for the development of complications after portosystemic shunting. Material and Methods: The present research involved 45 patients with liver cirrhosis complicated by portal hypertension. Buccal swabs and spot urine samples were used to determine acetylation phenotypes. The genotype of each individual was determined by polymerase chain reaction. High-performance liquid chromatography was used to determine acetylation phenotypes. Results: Rapid acetylation was revealed in 7 patients (15.6%) and slow acetylation was found in 38 patients (84.4%). In slow acetylation phenotype, a considerable progression of liver cirrhosis was observed in comparison with rapid acetylators alanin aminotransferaz (ALT) on 74.4 % in slow acetylation phenotype (SAcP) against 29.5 % in rapid acetylation phenotype (RAcP); total bilirubin on 111.8 % in comparison with 42%, respectively; the level of ammonia in blood was 247.8% compared to 62.5%). Recommendation: Taking into consideration the acetylation phenotype of liver cirrhosis patients can help in predicting possible side-effects and evaluate efficiency of drugs that are metabolized by N-acetylation. Acetylation Phenotype Viral Liver Cirrhosis Portal Hypertension Central Portosystemic Shunting Postoperative Period