Scienceline Publications Journal of Life Science and Biomedicine 2251-9939 9 4 2019 July Characteristics and early clinical outcomes of patients undergoing living-related kidney transplantation 96 101 https://jlsb.science-line.com/attachments/article/71/J.%20Life%20Sci.%20Biomed.%209(4)%2096-101,%202019.pdf EN Feruz Gafurovich NAZIROV Director of Republican Specialized Scientific-Practical Medical Center of Surgery named after Academician V.Vakhidov, Tashkent, Uzbekistan Fazliddin Shamsitdinovich BAKHRITDINOV Department of Vascular Surgery and Kidney Transplantation, Republican Specialized Scientific-Practical Medical Center of Surgery named after Academician V.Vakhidov, Tashkent, Uzbekistan Ravshan Aliyevich IBADOV Intensive Care Unit, Republican Specialized Scientific-Practical Medical Center of Surgery named after Academician V.Vakhidov, Tashkent, Uzbekistan Zokhidjon Turdaliyevich MATKARIMOV Department of Vascular Surgery and Kidney Transplantation, Republican Specialized Scientific-Practical Medical Center of Surgery named after Academician V.Vakhidov, Tashkent, Uzbekistan Azamat Sayfullayevich SUYUMOV Department of Vascular Surgery and Kidney Transplantation, Republican Specialized Scientific-Practical Medical Center of Surgery named after Academician V.Vakhidov, Tashkent, Uzbekistan Jasur Gaybillayevich SOBIROV Department of Vascular Surgery and Kidney Transplantation, Republican Specialized Scientific-Practical Medical Center of Surgery named after Academician V.Vakhidov, Tashkent, Uzbekistan Sardor Khamdamovich IBRAGIMOV Intensive Care Unit, Republican Specialized Scientific-Practical Medical Center of Surgery named after Academician V.Vakhidov, Tashkent, Uzbekistan Aim. This study aimed to access early outcomes of living-related kidney transplantation. Methods. The results of treatment of 159 patients (135 males and 24 females) with chronic renal disease during 2010- 2018, have been investigated. Two new and traditional methods have been studied. New optimized method was performed for the main group (n=98) observed since February 2018, while the comparison group (n=61) from 2010 to February 2018 was operated in the traditional way. The characteristics of the patients were compared using the Wilcoxon rank-sum test or the Fisher’s exact test as appropriate. All tests were two-sided, and P/0.05 was considered statistically significant. Analyses were performed using the R statistical package. Results. In 149 (93.7%) cases, the functional activity of the kidney transplants was assessed as a primary functioning graft with 95 (96.9%) cases in the main group and 54 (88.5%) in comparison group (P=0.048). Delayed graft function was detected in 2 (2.0%) recipients of the main group and in 5 (8.2%) cases of the comparison group. In the postoperative period, a significant decrease in creatinine level was observed in the main group of recipients and on the 1st day it was 221.0±58.7μmol/L, whereas in the comparison group the index was 569.3±84.6 μmol/L (P/0.001). 3-4 days after surgery, the level of blood creatinine in the main group was significantly (P/0.01) lower than the comparison group (149.6±25.6 vs. 343.6±69.4 μmol/L). On the first day after surgery, there was also a significant decrease (P/0.05) in urea level of the main group (11.4±1.61 mmol/L) in comparison with the comparative group (15.4±0.84 mmol/L). At the time of hospital discharge of recipients, the level of urea was within normal limits and equal to 8.3±0.80 mmol/L and 9.0±0.95 mmol/L in the main and comparison groups, respectively (P>0.05). Hemodialysis was required in 3 (3.1%) recipients from the main group and 3 (4.9%) from the comparison group. The need for corticosteroid therapy was observed in 2 (2.0%) cases of the main group and in 3 (4.9%) cases from the comparison group. Conclusion. The effectiveness of improved approaches to patient management and surgical tactics of related kidney transplantation has been proved, taking into account the verification of the graft functional activity on the main clinical and biochemical data of the terminal stage of chronic renal failure regression. Kidney Transplantation Living-Related Renal Transplant Recipients Early Clinical Outcomes