Journal of Life Science and Biomedicine
J Life Sci Biomed, 9 (2): 42-44, 2019
License: CC BY 4.0
The use of a new hemostatic preparation
made of the cellulose derivatives in
surgery: “warning” for postoperative
Gianluca Franceschini (MD), Alba Di Leone (MD), Giuseppe Visconti (MD), Riccardo Masetti (MD)
Division of Breast Surgery, Department of Women's and Children's Health, Fondazione Policlinico Universitario A. Gemelli IRCCS;
Università Cattolica del Sacro Cuore, Largo A. Gemelli, 8 - 00168, Rome, Italy.
Corresponding author: Prof. Dr. Gianluca Franceschini; Email: firstname.lastname@example.org
Letter to Editor
Introduction. We have read with interest the article by Rustam Abrarovich Sadykov et al.
(2019) on “New hemostatic preparation made of the cellulose derivatives” . The Authors
present their early experience on new samples of pellicle hemostatic coverage on the basis of
the cellulose derivatives. They conclude: “Rapid enough biodegradation of polymer along
with the unexpressed inflammatory reaction allows preventing the infecting related to the
presence of foreign body. The rapid forming of fibrotic tissue in a zone of lesion makes it
possible to obtain a durable hemostasis”.
Rec. 18 February 2019
Rev. 23 March 2019
Pub. 25 March 2019
Results. In our series we noted a 10% rate of allergic skin reactions with irritation, redness,
itching, swelling, rash and hives in the mammary region, successfully managed with
steroids and antihistamine medications. In addition, we experienced a significant seroma in
the site of oxidized regenerated cellulose (ORC) placement in 45% of our patients.
Conclusion and Recommendation. When using a new preparation made of the cellulose
derivatives, as a possible aid to reduce the risk of postoperative haematoma and infections it
is important to discuss with the patient also about possible postoperative complications. It
is also important that surgeons specify clearly the use of this biomaterial in the report of the
surgical procedure so that radiologists can properly interpret the sonographic findings due
to this biomaterial and avoid misdiagnosis and undue alarmism during the follow-up of
We have previously reported our experience with the use of oxidized regenerated cellulose (ORC), at the
Catholic Breast Unit of Rome, as a possible aid to reduce the risk of postoperative haematoma and infections
and to improve the aesthetic outcomes in patients undergoing an oncoplastic procedures for breast cancer [2, 3].
However, as new hemostatic preparations made of the cellulose derivatives is being increasingly utilized
in surgery [1-6], we think that it is important to properly inform the patients not only about the potential
advantages but also about possible postoperative complications of these materials. Tanaka et al.  report a 18%
rate of allergic reaction with the use of ORC, mainly presenting as acute dermatitis and eczema, and one case of
exudation followed by wound dehiscence .
In our series we noted a 10% rate of allergic skin reactions with irritation, redness, itching, swelling, rash
and hives in the mammary region, successfully managed with steroids and antihistamine medications. In
addition, we experienced a significant seroma in the site of ORC placement in 45% of our patients . This
seroma, that appears in the early postoperative period as consequence of redundant ORC digestion, normally
resolved within few weeks with repeated percutaneous aspirations but in two cases it was followed by the
To cite this paper: Franceschini G, Di Leone A, Visconti G, Masetti R 2019. The use of a new hemostatic preparation made of the cellulose derivatives in surgery: